What also follows from that is that, if you want to identify a treatment for a genetic mutation such as Down syndrome, you may not have to go to its source, that extra chromosome 21: You could seek to alter gene expression almost anywhere else in the genome, since that is how far-flung the effects of that mutation are. Browse 1000s of icons & templates from many fields of life sciences. And if they’re not random, they can (someday) be understood. A genetic disorder is a disease caused in whole or in part by a change in the DNA sequence away from the normal sequence. If they are organized functionally, they’re not random. The affected individual may inherit an extra part of chromosome 21 or an entire extra copy of chromosome 21, a condition known as trisomy 21. They found that when gene expression is altered by, say, an added chromosome, it is altered in consistent patterns in every chromosome, not just the one with the irregularity.Ī few things follow from that: First, it lends credence to scientists’ long-running suspicion that chromosomes - between 50 and 100 base pairs of DNA - may be organized along functional lines, such that certain stretches of a chromosome may hold the genetic blueprint for proteins that work together in some predictable way. Down syndrome, also called Down’s syndrome, trisomy 21, or (formerly) mongolism, congenital disorder caused by the presence in the human genome of extra genetic material from chromosome 21. That natural experiment allowed a group of geneticists from Switzerland, Spain, the Netherlands and France to distill some fundamental insights into how chromosomes - and the genetic blueprints they contain - dictate the behavior of cells across the body.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |