investigators will compare two independent groups: patients and controlsĪfter signing the informed consent each patient TGA will receive a neuropsychological assessment, a topographic MRI and an evaluation in resting state fMRI during three successive visits: The total duration of the study will not exceed 27 months.Īrm number or label and arm type: This study is exploratory. investigators will compare two independent groups: patients and controls We expect three months between the signing of consent and the end of the study. Monocentric, pilot, prospective, controlled study including consecutive patients admitted to the emergency department of the CHU of Toulouse for transient global amnesia. Describe the evolution of functional impairment in resting state fMRI between the acute phase (visit 1) and post-acute phases (visit 2 and 3) in the patient group compared to the control group subjects.Show correlations between functional activity observed in resting state fMRI at the acute phase and cognitive performance in the patient group.a group of healthy subjects during the acute phase of transient global amnesia (TGA) using resting state fMRI imaging. The main aim of this study is to identify neuronal functional impairment in a group of patients vs. Structural MRI can confirm the diagnosis by revealing a focal and selective lesion located on the CA1 region of the hippocampus better observed between 48h and 72h after onset of the episode. The age of patients affected is between 50 and 70 years. It involves 3-8 per 100,000 people per year. Its pathophysiology is poorly known, but the disease process involves the Papez circuitry, and more specifically the medial part of the temporal lobes (hippocampi). The transient global amnesia is a transient, massive and pure memory disorder. Two imaging exams (topographic MRI and resting state fMRI) and neuropsychological assessment will be performed during three visits. For the patients willing to participate, inclusion and exclusion criteria will be verified. If the patient is eligible and would like to participate, information will be given. Patients potentially eligible will be informed during their arrival to the emergency unit. control group during the acute phase of transient global amnesia (TGA) using resting state imaging. The main aim of this study will be to identify functional impairment in the patient group vs. investigators believe that the alteration of the functional network will explain the depth of memory impairment observed. Investigators hypothesize that despite limited structural lesions, a large functional network is impaired compared to that observed in a group of healthy subjects. This technique appears to be modern and adapted to these patients population. Thus, investigators wish to study the neural networks involved in memory impairment during the acute phase of transient global amnesia using resting state imaging. To our knowledge, no study has been performed to identify this functional impairment using resting state fMRI. This suggests that functional impairment goes far beyond the structural damage in this condition. There is therefore a real dissociation between structural lesions witch are minimal or non-existent and the massive memory disorder. Topographic MRI can reveal a focal and selective lesion located on the CA1 region of the hippocampus better visible between 48h and 72h after onset of the episode. The transient global amnesia, in which the memory disorder is massive, transient and pure, offers a unique model for exploring episodic memory. Why Should I Register and Submit Results?.
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